Aciphex (Rabeprazole) Drug Information

  • Why is this medication prescribed?

    Aciphex (rabeprazole) is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube that connects the throat and stomach). Aciphex (rabeprazole) is used to treat the symptoms of GERD, allow the esophagus to heal, and prevent further damage to the esophagus. Aciphex (rabeprazole) is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Aciphex (rabeprazole) is used to treat ulcers (sores in the lining of the stomach or intestine) and is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Aciphex (rabeprazole) is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.

  • How should this medicine be used?

    Aciphex (rabeprazole) comes as a delayed-release (long-acting) tablet to take by mouth. When Aciphex (rabeprazole) is used to treat most conditions, it is usually taken once a day. When used to treat ulcers, Aciphex (rabeprazole) is taken after the morning meal. When used in combination with other medications to eliminate H. pylori, Aciphex (rabeprazole) is taken twice a day, with the morning and evening meals, for 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Aciphex (rabeprazole) exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

    Swallow the tablets whole with water; do not split, chew, or crush them.

    Continue to take Aciphex (rabeprazole) even if you feel well. Do not stop taking Aciphex (rabeprazole) without talking to your doctor. If your condition does not improve or gets worse, call your doctor.

  • Other uses for this medicine

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

  • What special precautions should I follow?

    Before taking Aciphex (rabeprazole):

    • tell your doctor and pharmacist if you are allergic to acyclovir (Zovirax), valacyclovir, or any other drugs.
    • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially cimetidine (Tagamet), probenecid (Benemid), and vitamins.
    • tell your doctor if you have or have ever had kidney or liver disease, problems with your immune system, human immunodeficiency virus infection (HIV), or acquired immunodeficiency syndrome (AIDS).
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking valacyclovir, call your doctor.
  • What special dietary instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

  • What should I do if I forget a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • What side effects can this medication cause?

    Aciphex (rabeprazole) may cause side effects. Tell your doctor if these symptoms are severe or do not go away:

    • headache
    • nausea
    • vomiting
    • diarrhea
    • stomach pain
    • constipation
    • gas
    • sore throat

    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

    • blistering or peeling skin
    • rash
    • hives
    • swelling of the eyes, face, mouth, lips, tongue, or throat
    • difficulty breathing or swallowing
    • irregular, fast, or pounding heartbeat
    • excessive tiredness
    • dizziness
    • lightheadedness
    • muscle spasms
    • uncontrollable shaking of a part of the body
    • seizures

    Aciphex (rabeprazole) may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

    People who take proton pump inhibitors such as Aciphex (rabeprazole) may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. The risk is highest in people who take high doses of one of these medications or take them for one year or longer. The risk may also be higher in people who are 50 years of age or older. Talk to your doctor about the risk of taking Aciphex (rabeprazole).

    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at] or by phone [1-800-332-1088].

  • What storage conditions are needed for this medicine?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

  • In case of emergency/overdose

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

  • What other information should I know?

    Keep all appointments with your doctor and the laboratory. Your doctor may order certain laboratory tests before and during your treatment.

    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Brand Names

    • AcipHex®